Essential Oil Studies and Conclusions

It is difficult to fund conventional drug studies as these are usually performed by the pharmaceutical industry. But, essential oils are natural plant-based substances and therefore hard to patent. This limits the interest by pharmaceuticals which in turn limits the research.

The research on essential oils that that is available shows positive effects for infections, pain, anxiety, depression, tumours, premenstrual syndrome, nausea, and others. 

We have created a list of all the essential oil research we know about and will update it when we find new studies.

References

Alexandrovich, I., Rakovitskaya, O., Kolmo, E., Sidorova, T., Shushunov, S. (2003). The effect of fennel (Foeniculum Volgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study. Alternative Therapies in Health and Medicine, 9(4), 58-61.

Al-Hader, A.A., Hasan, Z.A., Aqel, M.B. (1994). Hyperglycemic and insulin release inhibitory effects of rosmarinus officinalis. Journal of Ethnopharmacology, 43, 217,2.

Al-Shuneigat, J., Cox, S. D., & Markham, J. L. (2005). Effects of a topical essential oil-containing formulation on biofilm-forming coagulase-negative staphylococci. Letters in Applied Microbiology, 41(1), 52-55.

Barker, S & Altman P. (2010). A randomized, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children - melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a "suffocation" product. BMC Dermatology, 10, 6.

Bassett, I. B., Pannowitz, D. L., & Barnetson, R. S. (1990). A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. Med J Aust, 153(8), 455-458.

Bernardes W, Lucarini R, Tozatti M, Flauzino L, Souza M, Turatti I, Andrade e Silva M, martins C, da Silva Filho A & Cunha W. (2010). Antibacterial activity of the essential oil from Rosmarinus officinalis and its major components against oral pathogens. Journal of Biosciences; 65(9-10):588-93.

Bouhdid, S, Abrini, J, Zhiri, A, Espuny, M & Manresa, A. (2009). Investigation of functional and morphological changes in Pseudomonas aeruginosa and Staphylococcus aureus cells induced by Origanum compactum essential oil. Journal of Applied Microbiology, 106(5), 1558-1568.

Brady, A., Loughlin, R., Gilpin, D., Kearney, P., & Tunney, M. (2006). In vitro activity of tea-tree oil against clinical skin isolates of meticillin-resistant and -sensitive staphylococcus aureus and coagulase-negative staphylococci growing planktonically and as biofilms. Journal of Medical Microbiology, 55(Pt 10), 1375-1380.

Brandao, F. M. (1986). Occupational allergy to lavender oil. Contact Dermatitis, 249-50.

Buckle, J. (2007). Literature review: should nursing take aromatherapy more seriously? British Journal of Nursing, 16(2), 116-120.

Burns, E., Blamey, C., Ersser, S. J., Barnetson, L., & Lloyd, A. (2000). An investigation into the use of aromatherapy in intrapartum midwifery Practice. The Journal of Alternative and Complementary Medicine, 6(2), 141-7.

Burns, E., Zobbi, V., Panzeri, D., Oskrochi, R., Regalia, A. (2007). Aromatherapy in childbirth: a pilot randomized controlled trial. BJOG: An International Journal of Obstetrics & Gynaecology, 114(7), 838-44.

Burt, S. A. (2003). Antibacterial activity of selected plant essential oils against Escherichia coli O157:H7. Letters in Applied Microbiology 36, 162-7.

Caelli, M., Porteous, J., Carlson, C. F., Heller, R., & Riley, T. V. (2001). Tea tree oil as an alternative topical decolonization agent for methicillin-resistant Staphylococcus Aureus. The International Journal of Aromatherapy, 11(2). [Originally published in The Journal of Hospital Infection (2000), 46, 236-237.]

Canyon, D & Speare, R. (2007). A comparison of botanical and synthetic substances commonly used to prevent health lice (Pediculus humanus var. capitis) infestation. International Journal of Dermatology, 46(4), 422-426.

Cappello, G, Spezzaferro, M, Grossi, L, et al. (2007). Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial. Digestive & Liver Disease, 39(6), 530-536.

Carson, C. F., Hammer, K. A., & Riley, T. V. (2006). Melaleuca alternifolia (tea tree) oil: A review of antimicrobial and other medicinal properties. Clinical Microbiology Reviews, 19(1), 50-62.

Chang, SY. (2008). Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer. Daehan Ganho Haghoeji, 38(4), 493-502.

Chung, M, Cho, S, Bhuiyan, M, Kim, K & Lee, S. (2010). Anti-diabetic effects of lemon balm (Melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice. British J of Nutrition, 104(2), 180-188.

Cooke, B., Ernst, E. (2000). Review: aromatherapy massage is associated with small, transient reductions in anxiety. British Journal of General Practice, 50, 493-6.

Davies, SJ, Harding, LM & Baranowski, AP. (2002). A novel treatment of postherpetic neuralgia using peppermint oil. Clinical Journal of Pain, 18(3), 200-2.

De Groot, A.C., & Weyland, W. (1992). Systemic contact dermatitis from tea tree oil. Contact Dermatitis, 27, 279-80.

Dryden, M., Dailly, S., Crouch, M. (2004). A randomized, controlled trial of tea tree topical preparations versus a standard topical regimen for the clearance of MRSA colonization. Journal of Hospital Infec, 56(4), 283-6.

Dwivedi, C. & Zhang, Y. (1999). Sandalwood oil prevents skin tumour development in CD1 mice. European Journal of Cancer Prevention, 8, 449-55.

Edris, A. (2007). Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: A review. Phytotherapy Research, 21, 308-323.

Enshaieh, S., Jooya, A., Siadat, A. H., & Iraji, F. (2007). The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: A randomized, double-blind placebo-controlled study. Indian Journal of Dermatology, Venereology & Leprology, 73(1), 22-25.

Furneri, P. M., Paolino, D., Saija, A., Marino, A., & Bisignano, G. (2006). In vitro antimycoplasmal activity of melaleuca alternifolia essential oil. Journal of Antimicrobial Chemotherapy, 58(3), 706-707.

Gao, Y. Y., Di Pascuale, M. A., Li, W., Baradaran-Rafii, A., Elizondo, A., Kuo, C. L., et al. (2005). In vitro and in vivo killing of ocular demodex by tea tree oil. British Journal of Ophthalmology, 89(11), 1468-1473.

Garozzo A, Timpanarao R, Stivala A, Bisignano G & Castro A. (2010) Activity of Melaleuca alternifolia (tea tree) oil on influenza virus A/PR/8: Study on the mechanism of action. Antiviral Research, 89(1), 83-8.

Gedney, J., Glover, T., Fillingim, R. (2004). Sensory and affective pain discrimination after inhalation of essential oils. Psychosomatic Medicine, 66(4), 599-606.

Greenway, f, Frome & Engels, T. (2003). Temporary relief of postherpetic neuralgia pain with topical geranium oil. American J of Medicine, 115, 586-587.

Gustafson, J. E., Chew, S., Markham, J., Bell, H.C., Wyllie, S. G., & Warmington, J. R. (1988). Effects of tea tree oil on Escherichia coli. Letters in Applied Microbiology, 26, 194-8.

Hadfield, N. (2001). The role of aromatherapy massage in reducing anxiety in patients with malignant brain tumors. International Journal of Palliative Nursing, 7(6), 279-285.

Hajhashemi, V., Ghannadi, A., & Sharif, B. (2003). Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of lavandula angustifolia mill. Journal of Ethnopharmacology, 89(1), 67-71.

Halm, M. (2008). Essential oils for management of symptoms in critically ill patients. American Journal of Critical Care, 17(2), 160-163.

Hammer, K. A., & Riley, T. V. (1998). In-vitro activity of essential oils, in particular Melaleuca alternifolia (tea tree) oil and tea tree oil products, against Candida spp. Journal of Antimicrobial Chemotherapy, 42, 591-5.

Hammer, K. A., Carson, C. F., & Riley, T. V. (2004). Antifungal effects of melaleuca alternifolia (tea tree) oil and its components on candida albicans, candida glabrata and saccharomyces cerevisiae. Journal of Antimicrobial Chemotherapy, 53(6), 1081-1085.

Hammer, K. A., Carson, C. F., Riley, T. V., & Nielsen, J. B. (2006). A review of the toxicity of Melaleuca alternifolia (tea tree) oil. Food & Chemical Toxicology, 44(5), 616-625.

Han, S., Hur M., Buckle, J., Choi, J., Lee, M. (2006). Effect of aromatherapy on symptoms of dysmenorrheal in college students: A randomized placebo-controlled clinical trial. The Journal of Alternative and Complentary Medicine, 12(6), 535-41.

Hansen, T., Hansen, B., Ringdal, G. (2006). Does aromatherapy massage reduce job-related stress? Results from a randomized, controlled trial. International Journal of Aromatherapy, 16(2), 89-94.

Hayashi, K., & Hayashi, T. (1994). Virucidal effects of the steam distilate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV. Planta Medica, 61, 237-41.

Haze, S, Sakai, K & Gozu, Y. (2002). Effects of fragrance inhalation on sympathetic activity in normal adults. Japanese Journal of Pharmacology, 90, 247-253.

Henley, D., Lipson, N., Korach, K., Bloch, C. (2007). Prepubertal gynecomastia linked to lavender and tea tree oils. The New England Journal of Medicine, 356(5), 479-485.

Inouye, S., Yamaguchi, H. (2001). Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact. Journal of Antimicrobial Chemotherapy, 47, 565-73.

Itai, T., Amayasu, H., Kuribayashi, M., Kawamura, N., Okada, M., Momose, A., Tateyama, T., Narumi, K., Waka, Kaneko, U.S. (2000). Psychological effects of aromatherapy on chronic hemodialysis patients. Psychiatry and Clinical Neurosciences, 54, 393-7.

Jandourek, A. & Vazquez, J. (1998). Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS, 12, 1033-7.

Kane, FM, Brodie, EE, Couli, A, et al. (2004). The analgesic effect of odour and music upon dressing change. British Journal of Nursing, 13(19), S4-12.

Kejova K, Jorova D, Bendova H, Gajdos P & Kolarova H. (2010). Phototoxicity of essential oils intended for cosmetic use. Toxicology in Vitro, 24(8), 2084-9.

Khan, M, Zahin & Hassan, S. (2009). Inhibition of quorum sensing regulated bacterial functions by plant essential oils with special reference to clove oil. Letters in Applied Microbiology, 49, 354-360.

Kim, J. et al. (2006). Evaluation of aromatherapy in treating post-operative pain: pilot study. Pain Practice, 6(4), 273-277.

Lehrner, J., Marwinski, G., Lehr, S., Johren, P., & Deecke, L. (2005). Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office. Physiology & Behavior, 86(1-2), 92-95.

Lemon, K. (2004). An assessment of treating depression and anxiety with aromatherapy. The International Journal of Aromatherapy, 14, 63-69.

Lucks, B.C., Sorensen, J., Veal, L. (2002). Vitex agnus-castus essential oil and menopausal balance: a self-care survey. Complementary Therapies in Nursing and Midwifery, 8, 148-54.

Messager, S., Hammer, K. A., Carson, C. F., & Riley, T. V. (2005). Assessment of the antibacterial activity of tea tree oil using the european EN 1276 and EN 12054 standard suspension tests. Journal of Hospital Infection, 59(2), 113-125.

Millar, B & Moore, J. (2008). Successful topical treatment of hand warts in a paediatric patient with tea tree oil (Melaleuca alternifolia). Complementary Therapies in Clinical Practice, 14(4), 225-27.

Nguyen, Q., Paton C. (2008). The use of aromatherapy to treat behavioral problems in dementia. International Journal of Geriatric Psychiatry, 23, 337-346.

Oyedele, A. O., Gbolade, A. A., Sosan, M.B., Adewoyin, F. B., Soyelu, O.L., & Orafidiya, O. O. (2002). Formulation of an effective mosquito-repellent topical product from Lemongrass oil. Phytomedicine, 9, 259-62.

Price, S. & Price, L. (2007). Aromatherapy for health professionals, 3rd Ed. Philadelphia: Churchill Livingstone Elsevier.

Rose, J. E. & Behm, F. M. (1994). Inhalation of vapor from black pepper extract reduced smoking withdrawal symptoms. Drug and Alcohol Dependence, 34, 225-9.

Saeki, Y. (2000). The effect of foot bath with or without the essential oil of lavender on the autonomic nervous system: A randomized trial. Complementary Therapies in Medicine, 8, 2-7.

Sharma S, Araujo M, Wu M, Qaqush J & Charles C. (2010). Superiority of an essential oil mouthrinse when compared with a 0.05% cetylpyridinium chloride containing mouthrinse: A six-month study. International Dental Journal, 60(3), 175-80.

Sherry, E., Warnke, P. H. (2001). Percutaneous treatment of chronic MRSA osteomyelitis with a novel plant-derived antiseptic. BMC Surgery, 1(1).

Snow L, Hovanec L & Brandt J. (2004). A controlled trial of aromatherapy for agitation in nursing home patients with dementia. J Alternative & Complementary Medicine, 10(3), 431-437.

Soukoulis, S., & Hirsch, R. (2004). The effects of a tea tree oil-containing gel on plaque and chronic gingivitis. Australian Dental Journal, 49(2), 78-83.

Srivasta, K. C., Mustafa, T. (1992). Ginger (Zingiber officinale) in Rheumatism and Musculoskeletal Disorders. Medical Hypotheses, 39, 342-8.

Takarada, R. et al. (2004). A comparison of the antibacterial efficacies of essential oils against oral pathogens. Oral Microbiology and Immunology, 19, 61-64.

Toloza A, Zygadlo J, Biurrun F, Rotman A & Picollo M. (2010). Bioactivity of Argentinean essential oils against permethrin-resistant head lice, Pediculus humanus capita. J of Insect Science, 10, 185.

Torres Salazar A, Hoheisel J, Youns M & Wink M. (2011). Anti-inflammatory and anti-cancer activities of essential oils and their biological constituents. International J of Clinical Pharmacology & Therapeutics, 49(1), 93-95.

Tyagi A & Malik A. (2010). Liquid and vapour-phase antifungal activities of selected essential oils against Candida albicans: Microscopic observations and chemical characterization of Cymbopogon citratus. BMC Complementary & Alternative Medicine, 10, 65.

Van der Ploeg E, Eppingstall B & O'Connor D. (2010). The study protocol of a blinded randomized-controlled cross-over trial of lavender oil as a treatment of behavioural symptoms in dementia. BMC Geriatrics, 10, 49.